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Cytolethal Distending Toxin Induces Caspase-Dependent and -Independent Cell Death in MOLT-4 Cells

Cytolethal distending toxin (CDT) induces apoptosis using the caspase-dependent classical pathway in the majority of human leukemic T cells (MOLT-4). However, we found the process to cell death is only partially inhibited by pretreatment of the cells with a general caspase inhibitor, z-VAD-fmk. Flow...

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Detalhes bibliográficos
Main Authors: Ohara, Masaru, Hayashi, Tomonori, Kusunoki, Yoichiro, Nakachi, Kei, Fujiwara, Tamaki, Komatsuzawa, Hitoshi, Sugai, Motoyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546834/
https://ncbi.nlm.nih.gov/pubmed/18644882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01612-07
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