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A Role for PP1 in the Cdc2/Cyclin B–mediated Positive Feedback Activation of Cdc25
The Cdc25 phosphatase promotes entry into mitosis through the removal of inhibitory phosphorylations on the Cdc2 subunit of the Cdc2/CyclinB complex. During interphase, or after DNA damage, Cdc25 is suppressed by phosphorylation at Ser287 (Xenopus numbering; Ser216 of human Cdc25C) and subsequent bi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1415323/ https://ncbi.nlm.nih.gov/pubmed/16467385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-08-0751 |
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