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PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation
It has been known for over a decade that inhibition of protein phosphatase 1 (PP1) activity prevents entry into M phase, but the relevant substrate has not been identified. We report here that PP1 is required for dephosphorylation of the Cdc2-directed phosphatase Cdc25 at Ser287 (of Xenopus Cdc25; S...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC275402/ https://ncbi.nlm.nih.gov/pubmed/14592972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg545 |
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