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PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation

It has been known for over a decade that inhibition of protein phosphatase 1 (PP1) activity prevents entry into M phase, but the relevant substrate has not been identified. We report here that PP1 is required for dephosphorylation of the Cdc2-directed phosphatase Cdc25 at Ser287 (of Xenopus Cdc25; S...

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Autori principali: Margolis, Seth S., Walsh, Susan, Weiser, Douglas C., Yoshida, Minoru, Shenolikar, Shirish, Kornbluth, Sally
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC275402/
https://ncbi.nlm.nih.gov/pubmed/14592972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg545
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