Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

DNA-responsive checkpoints prevent cell cycle progression following DNA damage or replication inhibition. The mitotic activator Cdc25 is suppressed by checkpoints through inhibitory phosphorylation at Ser287 (Xenopus numbering) and docking of 14-3-3. S287 phosphorylation is a major locus of G2/M che...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Margolis, Seth S., Perry, Jennifer A., Forester, Craig M., Nutt, Leta K., Guo, Yanxiang, Jardim, Melanie J., Thomenius, Michael J., Freel, Christopher D., Darbandi, Rashid, Ahn, Jung-Hyuck, Arroyo, Jason D., Wang, Xiao-Fan, Shenolikar, Shirish, Nairn, Angus C., Dunphy, William G., Hahn, William C., Virshup, David M., Kornbluth, Sally
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789796/
https://ncbi.nlm.nih.gov/pubmed/17110335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.10.035
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi