Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

DNA-responsive checkpoints prevent cell cycle progression following DNA damage or replication inhibition. The mitotic activator Cdc25 is suppressed by checkpoints through inhibitory phosphorylation at Ser287 (Xenopus numbering) and docking of 14-3-3. S287 phosphorylation is a major locus of G2/M che...

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Main Authors: Margolis, Seth S., Perry, Jennifer A., Forester, Craig M., Nutt, Leta K., Guo, Yanxiang, Jardim, Melanie J., Thomenius, Michael J., Freel, Christopher D., Darbandi, Rashid, Ahn, Jung-Hyuck, Arroyo, Jason D., Wang, Xiao-Fan, Shenolikar, Shirish, Nairn, Angus C., Dunphy, William G., Hahn, William C., Virshup, David M., Kornbluth, Sally
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789796/
https://ncbi.nlm.nih.gov/pubmed/17110335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.10.035
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