A Role for PP1 in the Cdc2/Cyclin B–mediated Positive Feedback Activation of Cdc25

The Cdc25 phosphatase promotes entry into mitosis through the removal of inhibitory phosphorylations on the Cdc2 subunit of the Cdc2/CyclinB complex. During interphase, or after DNA damage, Cdc25 is suppressed by phosphorylation at Ser287 (Xenopus numbering; Ser216 of human Cdc25C) and subsequent bi...

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Main Authors: Margolis, Seth S., Perry, Jennifer A., Weitzel, Douglas H., Freel, Christopher D., Yoshida, Minoru, Haystead, Timothy A., Kornbluth, Sally
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2006
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1415323/
https://ncbi.nlm.nih.gov/pubmed/16467385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-08-0751
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