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A photocleavable fluorescent nucleotide for DNA sequencing and analysis

DNA sequencing by synthesis during a polymerase reaction using laser-induced fluorescence detection is an approach that has a great potential to increase the throughput and data quality of DNA sequencing. We report the design and synthesis of a photocleavable fluorescent nucleoside triphosphate, one...

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Main Authors: Li, Zengmin, Bai, Xiaopeng, Ruparel, Hameer, Kim, Sobin, Turro, Nicholas J., Ju, Jingyue
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC141009/
https://ncbi.nlm.nih.gov/pubmed/12515853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242729199
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