Progressively impaired proteasomal capacity during terminal plasma cell differentiation

After few days of intense immunoglobulin (Ig) secretion, most plasma cells undergo apoptosis, thus ending the humoral immune response. We asked whether intrinsic factors link plasma cell lifespan to Ig secretion. Here we show that in the late phases of plasmacytic differentiation, when antibody prod...

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Hlavní autoři: Cenci, Simone, Mezghrani, Alexandre, Cascio, Paolo, Bianchi, Giada, Cerruti, Fulvia, Fra, Anna, Lelouard, Hugues, Masciarelli, Silvia, Mattioli, Laura, Oliva, Laura, Orsi, Andrea, Pasqualetto, Elena, Pierre, Philippe, Ruffato, Elena, Tagliavacca, Luigina, Sitia, Roberto
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409720/
https://ncbi.nlm.nih.gov/pubmed/16498407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601009
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