A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counterpart of MM. Here, integrating proteomics...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Milan, Enrico, Perini, Tommaso, Resnati, Massimo, Orfanelli, Ugo, Oliva, Laura, Raimondi, Andrea, Cascio, Paolo, Bachi, Angela, Marcatti, Magda, Ciceri, Fabio, Cenci, Simone
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Translational Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590585/
https://ncbi.nlm.nih.gov/pubmed/26043024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1052928
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