A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counterpart of MM. Here, integrating proteomics...

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書目詳細資料
發表在:Autophagy
Main Authors: Milan, Enrico, Perini, Tommaso, Resnati, Massimo, Orfanelli, Ugo, Oliva, Laura, Raimondi, Andrea, Cascio, Paolo, Bachi, Angela, Marcatti, Magda, Ciceri, Fabio, Cenci, Simone
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2015
主題:
Translational Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590585/
https://ncbi.nlm.nih.gov/pubmed/26043024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1052928
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