A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counterpart of MM. Here, integrating proteomics...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Milan, Enrico, Perini, Tommaso, Resnati, Massimo, Orfanelli, Ugo, Oliva, Laura, Raimondi, Andrea, Cascio, Paolo, Bachi, Angela, Marcatti, Magda, Ciceri, Fabio, Cenci, Simone
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Translational Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590585/
https://ncbi.nlm.nih.gov/pubmed/26043024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1052928
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