A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counterpart of MM. Here, integrating proteomics...

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Bibliographische Detailangaben
Veröffentlicht in:Autophagy
Hauptverfasser: Milan, Enrico, Perini, Tommaso, Resnati, Massimo, Orfanelli, Ugo, Oliva, Laura, Raimondi, Andrea, Cascio, Paolo, Bachi, Angela, Marcatti, Magda, Ciceri, Fabio, Cenci, Simone
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Translational Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590585/
https://ncbi.nlm.nih.gov/pubmed/26043024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1052928
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