A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counterpart of MM. Here, integrating proteomics...

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Bibliografische gegevens
Gepubliceerd in:Autophagy
Hoofdauteurs: Milan, Enrico, Perini, Tommaso, Resnati, Massimo, Orfanelli, Ugo, Oliva, Laura, Raimondi, Andrea, Cascio, Paolo, Bachi, Angela, Marcatti, Magda, Ciceri, Fabio, Cenci, Simone
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
Onderwerpen:
Translational Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590585/
https://ncbi.nlm.nih.gov/pubmed/26043024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1052928
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