CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

Upon antigen stimulation, B lymphocytes differentiate into antibody secreting cells (ASC), most of which undergo apoptosis after a few days of intense Ig production. Differentiation entails expansion of the endoplasmic reticulum (ER) and requires XBP1 but not other elements of the unfolded protein r...

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Detalhes bibliográficos
Main Authors: Masciarelli, Silvia, Fra, Anna M., Pengo, Niccoló, Bertolotti, Milena, Cenci, Simone, Fagioli, Claudio, Ron, David, Hendershot, Linda M, Sitia, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830287/
https://ncbi.nlm.nih.gov/pubmed/20044139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.12.003
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