Macroautophagy Is Regulated by the UPR–Mediator CHOP and Accentuates the Phenotype of SBMA Mice

Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a neuromuscular disorder caused by a CAG/glutamine expansion in the androgen receptor. Here we show that the unfolded protein response (UPR), an ER protei...

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Detalhes bibliográficos
Main Authors: Yu, Zhigang, Wang, Adrienne M., Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Yue, Zhenyu, Robins, Diane M., Lieberman, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192827/
https://ncbi.nlm.nih.gov/pubmed/22022281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002321
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