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Macroautophagy Is Regulated by the UPR–Mediator CHOP and Accentuates the Phenotype of SBMA Mice

Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a neuromuscular disorder caused by a CAG/glutamine expansion in the androgen receptor. Here we show that the unfolded protein response (UPR), an ER protei...

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Hlavní autoři: Yu, Zhigang, Wang, Adrienne M., Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Yue, Zhenyu, Robins, Diane M., Lieberman, Andrew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192827/
https://ncbi.nlm.nih.gov/pubmed/22022281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002321
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