CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model

Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine tract within the androgen receptor (AR). The pathologic features of SBMA are motor neuron loss in the spinal cord and brainstem and diffuse nuclear accumulation and nuclear inclu...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Adachi, Hiroaki, Waza, Masahiro, Tokui, Keisuke, Katsuno, Masahisa, Minamiyama, Makoto, Tanaka, Fumiaki, Doyu, Manabu, Sobue, Gen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2007
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672370/
https://ncbi.nlm.nih.gov/pubmed/17494697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1242-07.2007
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