Disrupted Transforming Growth Factor-β Signaling in Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) is a late-onset lower motor neuron disease caused by the expansion of a trinucleotide CAG repeat, which encodes a polyglutamine tract in androgen receptor (AR). Although it is commonly held that the pathogenic polyglutamine proteins accumulate in neurons and...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Katsuno, Masahisa, Adachi, Hiroaki, Minamiyama, Makoto, Waza, Masahiro, Doi, Hideki, Kondo, Naohide, Mizoguchi, Hiroyuki, Nitta, Atsumi, Yamada, Kiyofumi, Banno, Haruhiko, Suzuki, Keisuke, Tanaka, Fumiaki, Sobue, Gen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632356/
https://ncbi.nlm.nih.gov/pubmed/20410122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0388-10.2010
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