Progressively impaired proteasomal capacity during terminal plasma cell differentiation

After few days of intense immunoglobulin (Ig) secretion, most plasma cells undergo apoptosis, thus ending the humoral immune response. We asked whether intrinsic factors link plasma cell lifespan to Ig secretion. Here we show that in the late phases of plasmacytic differentiation, when antibody prod...

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Bibliografiske detaljer
Main Authors: Cenci, Simone, Mezghrani, Alexandre, Cascio, Paolo, Bianchi, Giada, Cerruti, Fulvia, Fra, Anna, Lelouard, Hugues, Masciarelli, Silvia, Mattioli, Laura, Oliva, Laura, Orsi, Andrea, Pasqualetto, Elena, Pierre, Philippe, Ruffato, Elena, Tagliavacca, Luigina, Sitia, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409720/
https://ncbi.nlm.nih.gov/pubmed/16498407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601009
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