Expression of Mutant or Cytosolic PrP in Transgenic Mice and Cells Is Not Associated with Endoplasmic Reticulum Stress or Proteasome Dysfunction

The cellular pathways activated by mutant prion protein (PrP) in genetic prion diseases, ultimately leading to neuronal dysfunction and degeneration, are not known. Several mutant PrPs misfold in the early secretory pathway and reside longer in the endoplasmic reticulum (ER) possibly stimulating ER...

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Detalhes bibliográficos
Main Authors: Quaglio, Elena, Restelli, Elena, Garofoli, Anna, Dossena, Sara, De Luigi, Ada, Tagliavacca, Luigina, Imperiale, Daniele, Migheli, Antonio, Salmona, Mario, Sitia, Roberto, Forloni, Gianluigi, Chiesa, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084828/
https://ncbi.nlm.nih.gov/pubmed/21559407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019339
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