Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α(2)δ-1 Subunit

How mutant prion protein (PrP) leads to neurological dysfunction in genetic prion diseases is unknown. Tg(PG14) mice synthesize a misfolded mutant PrP which is partially retained in the neuronal endoplasmic reticulum (ER). As these mice age, they develop ataxia and massive degeneration of cerebellar...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Senatore, Assunta, Colleoni, Simona, Verderio, Claudia, Restelli, Elena, Morini, Raffaella, Condliffe, Steven B., Bertani, Ilaria, Mantovani, Susanna, Canovi, Mara, Micotti, Edoardo, Forloni, Gianluigi, Dolphin, Annette C., Matteoli, Michela, Gobbi, Marco, Chiesa, Roberto
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cell Press 2012
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339322/
https://ncbi.nlm.nih.gov/pubmed/22542184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.02.027
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