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Cell Type-Specific Neuroprotective Activity of Untranslocated Prion Protein

BACKGROUND: A key pathogenic role in prion diseases was proposed for a cytosolic form of the prion protein (PrP). However, it is not clear how cytosolic PrP localization influences neuronal viability, with either cytotoxic or anti-apoptotic effects reported in different studies. The cellular mechani...

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Detalhes bibliográficos
Main Authors: Restelli, Elena, Fioriti, Luana, Mantovani, Susanna, Airaghi, Simona, Forloni, Gianluigi, Chiesa, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965675/
https://ncbi.nlm.nih.gov/pubmed/21060848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013725
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