Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In higher eukaryotes, regulation of the licensing factor Cdt1 by proteolysis and Geminin is essential to prevent re-replication. We show here that the N-terminal 100 amino acids of human Cdt1 are recognized...

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Main Authors: Nishitani, Hideo, Sugimoto, Nozomi, Roukos, Vassilis, Nakanishi, Yohsuke, Saijo, Masafumi, Obuse, Chikashi, Tsurimoto, Toshiki, Nakayama, Keiichi I, Nakayama, Keiko, Fujita, Masatoshi, Lygerou, Zoi, Nishimoto, Takeharu
格式: Artigo
語言:Inglês
出版: 2006
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409712/
https://ncbi.nlm.nih.gov/pubmed/16482215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601002
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