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The Caenorhabditis elegans Replication Licensing Factor CDT-1 Is Targeted for Degradation by the CUL-4/DDB-1 Complex

The replication of genomic DNA is strictly regulated to occur only once per cell cycle. This regulation centers on the temporal restriction of replication licensing factor activity. Two distinct ubiquitin ligase (E3) complexes, CUL4/DDB1 and SCF(Skp2), have been reported to target the replication li...

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Autores principales: Kim, Youngjo, Kipreos, Edward T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800708/
https://ncbi.nlm.nih.gov/pubmed/17145765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00736-06
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