β-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of β2 adrenergic receptor Gαs signaling in 3T3-L1 adipocytes
β-Arrestin 1 is required for internalization and mitogen-activated protein (MAP) kinase activation by the β2 adrenergic receptor (β2AR). Our previous studies have shown that chronic insulin treatment down-regulates cellular β-arrestin 1 levels, leading to a marked impairment in G protein-coupled rec...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140914/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12509508/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0235674100 |
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