A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239Δnef Increases Viral Replication

The live, attenuated vaccine simian immunodeficiency virus SIVmac239Δnef efficiently protects rhesus macaques against infection with wild-type SIVmac but occasionally causes CD4(+) T-cell depletion and progression to simian AIDS (SAIDS). Virus recovered from a vaccinated macaque (Rh1490) that progre...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Chakrabarti, Lisa A., Metzner, Karin J., Ivanovic, Tijana, Cheng, Hua, Louis-Virelizier, Jean, Connor, Ruth I., Cheng-Mayer, Cecilia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502842/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.2.1245-1256.2003
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