A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239Δnef Increases Viral Replication

The live, attenuated vaccine simian immunodeficiency virus SIVmac239Δnef efficiently protects rhesus macaques against infection with wild-type SIVmac but occasionally causes CD4(+) T-cell depletion and progression to simian AIDS (SAIDS). Virus recovered from a vaccinated macaque (Rh1490) that progre...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Chakrabarti, Lisa A., Metzner, Karin J., Ivanovic, Tijana, Cheng, Hua, Louis-Virelizier, Jean, Connor, Ruth I., Cheng-Mayer, Cecilia
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502842/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.2.1245-1256.2003
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