A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239Δnef Increases Viral Replication

The live, attenuated vaccine simian immunodeficiency virus SIVmac239Δnef efficiently protects rhesus macaques against infection with wild-type SIVmac but occasionally causes CD4(+) T-cell depletion and progression to simian AIDS (SAIDS). Virus recovered from a vaccinated macaque (Rh1490) that progre...

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Autori principali: Chakrabarti, Lisa A., Metzner, Karin J., Ivanovic, Tijana, Cheng, Hua, Louis-Virelizier, Jean, Connor, Ruth I., Cheng-Mayer, Cecilia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC140812/
https://ncbi.nlm.nih.gov/pubmed/12502842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1245-1256.2003
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