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PDE5 is converted to an activated state upon cGMP binding to the GAF A domain
cGMP-specific, cGMP-binding phosphodiesterase (PDE5) regulates such physiological processes as smooth muscle relaxation and neuronal survival. PDE5 contains two N-terminal domains (GAF A and GAF B), but the functional roles of these domains have not been determined. Here we show that recombinant PDE...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140735/ https://ncbi.nlm.nih.gov/pubmed/12554648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg051 |
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