The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites an...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Yu, Sung-Lim, Lee, Sung-Keun, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2003
Assuntos:	DNA Dynamics and Chromosome Structure
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140683/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12482989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.1.382-388.2003
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