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The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites an...

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書誌詳細
主要な著者: Yu, Sung-Lim, Lee, Sung-Keun, Johnson, Robert E., Prakash, Louise, Prakash, Satya
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC140683/
https://ncbi.nlm.nih.gov/pubmed/12482989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.382-388.2003
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