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The Stalling of Transcription at Abasic Sites Is Highly Mutagenic
Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites an...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2003
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140683/ https://ncbi.nlm.nih.gov/pubmed/12482989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.382-388.2003 |
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