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The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites an...

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Publicado no:Mol Cell Biol
Principais autores: Yu, Sung-Lim, Lee, Sung-Keun, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140683/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12482989/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.1.382-388.2003
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