The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites an...

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में प्रकाशित:	Mol Cell Biol
मुख्य लेखकों:	Yu, Sung-Lim, Lee, Sung-Keun, Johnson, Robert E., Prakash, Louise, Prakash, Satya
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Taylor & Francis 2003
विषय:	DNA Dynamics and Chromosome Structure
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140683/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12482989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.1.382-388.2003
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