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The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites an...

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Gepubliceerd in:Mol Cell Biol
Hoofdauteurs: Yu, Sung-Lim, Lee, Sung-Keun, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2003
Onderwerpen:
DNA Dynamics and Chromosome Structure
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140683/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12482989/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.1.382-388.2003
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