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Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen

Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus 40 (SV40) large T antigen is one of the central features of tumorigenesis induced by SV40. Both the N-terminal J domain and the LxCxE motif of large T antigen are required for inactivation of Rb. The crystal structure of the N-...

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Udgivet i:EMBO J
Principais autores: Kim, Hye-Yeon, Ahn, Byung-Yoon, Cho, Yunje
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140208/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226179/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.1.295
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