Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen
Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus 40 (SV40) large T antigen is one of the central features of tumorigenesis induced by SV40. Both the N-terminal J domain and the LxCxE motif of large T antigen are required for inactivation of Rb. The crystal structure of the N-...
Enregistré dans:
| Publié dans: | EMBO J |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2001
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140208/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226179/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.1.295 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|