Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen
Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus 40 (SV40) large T antigen is one of the central features of tumorigenesis induced by SV40. Both the N-terminal J domain and the LxCxE motif of large T antigen are required for inactivation of Rb. The crystal structure of the N-...
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| Publicado no: | EMBO J |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140208/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226179/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.1.295 |
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