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Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen

Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus 40 (SV40) large T antigen is one of the central features of tumorigenesis induced by SV40. Both the N-terminal J domain and the LxCxE motif of large T antigen are required for inactivation of Rb. The crystal structure of the N-...

詳細記述

保存先:
書誌詳細
主要な著者: Kim, Hye-Yeon, Ahn, Byung-Yoon, Cho, Yunje
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC140208/
https://ncbi.nlm.nih.gov/pubmed/11226179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.1.295
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