Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under hypoxic conditions, the HIF-1α subunit accumulates due to a decrease in the rate of proteolytic degradation, and the resu...

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Главные авторы: Hudson, Christine C., Liu, Mei, Chiang, Gary G., Otterness, Diane M., Loomis, Dawn C., Kaper, Fiona, Giaccia, Amato J., Abraham, Robert T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2002
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC139825/
https://ncbi.nlm.nih.gov/pubmed/12242281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.7004-7014.2002
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