p21(Cip1) and p27(Kip1) Regulate Cell Cycle Reentry after Hypoxic Stress but Are Not Necessary for Hypoxia-Induced Arrest

We investigated the role of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) in cell cycle regulation during hypoxia and reoxygenation. While moderate hypoxia (1 or 0.1% oxygen) does not significantly impair bromodeoxyuridine incorporation, at very low oxygen tensions (0.01% oxygen) DN...

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Hlavní autoři: Green, Susannah L., Freiberg, Rachel A., Giaccia, Amato J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC99573/
https://ncbi.nlm.nih.gov/pubmed/11158306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1196-1206.2001
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