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p21(Cip1) and p27(Kip1) Regulate Cell Cycle Reentry after Hypoxic Stress but Are Not Necessary for Hypoxia-Induced Arrest

We investigated the role of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) in cell cycle regulation during hypoxia and reoxygenation. While moderate hypoxia (1 or 0.1% oxygen) does not significantly impair bromodeoxyuridine incorporation, at very low oxygen tensions (0.01% oxygen) DN...

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Publicat a:Mol Cell Biol
Autors principals: Green, Susannah L., Freiberg, Rachel A., Giaccia, Amato J.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2001
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99573/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158306/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.4.1196-1206.2001
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