A Two-Stage, p16(INK4A)- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

With increasing frequency during serial passage in culture, primary human keratinocytes express p16(INK4A) (p16) and undergo senescence arrest. Keratinocytes engineered to express hTERT maintain long telomeres but typically are not immortalized unless, by mutation or other heritable event, they avoi...

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Bibliografiska uppgifter
Huvudupphovsmän: Rheinwald, James G., Hahn, William C., Ramsey, Matthew R., Wu, Jenny Y., Guo, Zongyou, Tsao, Hensin, De Luca, Michele, Catricalà, Caterina, O'Toole, Kathleen M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2002
Ämnen:
Cell Growth and Development
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC139780/
https://ncbi.nlm.nih.gov/pubmed/12077343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.14.5157-5172.2002
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