Regulation of p53 during senescence in normal human keratinocytes

p53, the guardian of the genome, is a tumor suppressor protein and critical for the genomic integrity of the cells. Many studies have shown that intracellular level of p53 is enhanced during replicative senescence in normal fibroblasts, and the enhanced level of p53 is viewed as the cause of senesce...

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Publicado en:Aging Cell
Autores principales: Kim, Reuben H, Kang, Mo K, Kim, Terresa, Yang, Paul, Bae, Susan, Williams, Drake W, Phung, Samantha, Shin, Ki-Hyuk, Hong, Christine, Park, No-Hee
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568971/
https://ncbi.nlm.nih.gov/pubmed/26138448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12364
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