A Two-Stage, p16(INK4A)- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

With increasing frequency during serial passage in culture, primary human keratinocytes express p16(INK4A) (p16) and undergo senescence arrest. Keratinocytes engineered to express hTERT maintain long telomeres but typically are not immortalized unless, by mutation or other heritable event, they avoi...

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Detalhes bibliográficos
Main Authors: Rheinwald, James G., Hahn, William C., Ramsey, Matthew R., Wu, Jenny Y., Guo, Zongyou, Tsao, Hensin, De Luca, Michele, Catricalà, Caterina, O'Toole, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139780/
https://ncbi.nlm.nih.gov/pubmed/12077343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.14.5157-5172.2002
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