A Two-Stage, p16(INK4A)- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

With increasing frequency during serial passage in culture, primary human keratinocytes express p16(INK4A) (p16) and undergo senescence arrest. Keratinocytes engineered to express hTERT maintain long telomeres but typically are not immortalized unless, by mutation or other heritable event, they avoi...

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Détails bibliographiques
Auteurs principaux: Rheinwald, James G., Hahn, William C., Ramsey, Matthew R., Wu, Jenny Y., Guo, Zongyou, Tsao, Hensin, De Luca, Michele, Catricalà, Caterina, O'Toole, Kathleen M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC139780/
https://ncbi.nlm.nih.gov/pubmed/12077343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.14.5157-5172.2002
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