Targeted Deletion of Both Thymidine Phosphorylase and Uridine Phosphorylase and Consequent Disorders in Mice

Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels. TP deficiency is hypothesized to (i) increase levels of thymidine in plasma, (ii) lead to mitochondrial DNA alterations, and (iii) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). In order to elucid...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Haraguchi, Misako, Tsujimoto, Hiroaki, Fukushima, Masakazu, Higuchi, Itsuro, Kuribayashi, Hideto, Utsumi, Hideo, Nakayama, Atsuo, Hashizume, Yoshio, Hirato, Junko, Yoshida, Hiroki, Hara, Hiromitsu, Hamano, Shinjiro, Kawaguchi, Hiroaki, Furukawa, Tatsuhiko, Miyazono, Kohei, Ishikawa, Fuyuki, Toyoshima, Hideo, Kaname, Tadashi, Komatsu, Masaharu, Chen, Zhe-Sheng, Gotanda, Takenari, Tachiwada, Tokushi, Sumizawa, Tomoyuki, Miyadera, Kazutaka, Osame, Mitsuhiro, Noda, Tetsuo, Yamada, Yuji, Akiyama, Shin-ichi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139774/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077348/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.5212-5221.2002
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