Targeted Deletion of Both Thymidine Phosphorylase and Uridine Phosphorylase and Consequent Disorders in Mice

Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels. TP deficiency is hypothesized to (i) increase levels of thymidine in plasma, (ii) lead to mitochondrial DNA alterations, and (iii) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). In order to elucid...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Haraguchi, Misako, Tsujimoto, Hiroaki, Fukushima, Masakazu, Higuchi, Itsuro, Kuribayashi, Hideto, Utsumi, Hideo, Nakayama, Atsuo, Hashizume, Yoshio, Hirato, Junko, Yoshida, Hiroki, Hara, Hiromitsu, Hamano, Shinjiro, Kawaguchi, Hiroaki, Furukawa, Tatsuhiko, Miyazono, Kohei, Ishikawa, Fuyuki, Toyoshima, Hideo, Kaname, Tadashi, Komatsu, Masaharu, Chen, Zhe-Sheng, Gotanda, Takenari, Tachiwada, Tokushi, Sumizawa, Tomoyuki, Miyadera, Kazutaka, Osame, Mitsuhiro, Noda, Tetsuo, Yamada, Yuji, Akiyama, Shin-ichi
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2002
Fag:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139774/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077348/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.5212-5221.2002
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