Targeted Deletion of Both Thymidine Phosphorylase and Uridine Phosphorylase and Consequent Disorders in Mice

Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels. TP deficiency is hypothesized to (i) increase levels of thymidine in plasma, (ii) lead to mitochondrial DNA alterations, and (iii) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). In order to elucid...

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發表在:	Mol Cell Biol
Principais autores:	Haraguchi, Misako, Tsujimoto, Hiroaki, Fukushima, Masakazu, Higuchi, Itsuro, Kuribayashi, Hideto, Utsumi, Hideo, Nakayama, Atsuo, Hashizume, Yoshio, Hirato, Junko, Yoshida, Hiroki, Hara, Hiromitsu, Hamano, Shinjiro, Kawaguchi, Hiroaki, Furukawa, Tatsuhiko, Miyazono, Kohei, Ishikawa, Fuyuki, Toyoshima, Hideo, Kaname, Tadashi, Komatsu, Masaharu, Chen, Zhe-Sheng, Gotanda, Takenari, Tachiwada, Tokushi, Sumizawa, Tomoyuki, Miyadera, Kazutaka, Osame, Mitsuhiro, Noda, Tetsuo, Yamada, Yuji, Akiyama, Shin-ichi
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis 2002
主題:	Mammalian Genetic Models with Minimal or Complex Phenotypes
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139774/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077348/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.5212-5221.2002
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