Targeted Deletion of Both Thymidine Phosphorylase and Uridine Phosphorylase and Consequent Disorders in Mice

Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels. TP deficiency is hypothesized to (i) increase levels of thymidine in plasma, (ii) lead to mitochondrial DNA alterations, and (iii) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). In order to elucid...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Haraguchi, Misako, Tsujimoto, Hiroaki, Fukushima, Masakazu, Higuchi, Itsuro, Kuribayashi, Hideto, Utsumi, Hideo, Nakayama, Atsuo, Hashizume, Yoshio, Hirato, Junko, Yoshida, Hiroki, Hara, Hiromitsu, Hamano, Shinjiro, Kawaguchi, Hiroaki, Furukawa, Tatsuhiko, Miyazono, Kohei, Ishikawa, Fuyuki, Toyoshima, Hideo, Kaname, Tadashi, Komatsu, Masaharu, Chen, Zhe-Sheng, Gotanda, Takenari, Tachiwada, Tokushi, Sumizawa, Tomoyuki, Miyadera, Kazutaka, Osame, Mitsuhiro, Noda, Tetsuo, Yamada, Yuji, Akiyama, Shin-ichi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2002
Schlagworte:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139774/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077348/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.5212-5221.2002
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