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Transforming growth factor-β and breast cancer: Cell cycle arrest by transforming growth factor-β and its disruption in cancer

Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitory signals. Transforming growth factor (TGF)-β mediates G(1) cell cycle arrest by inducing o...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Principais autores: Donovan, Jeffrey, Slingerland, Joyce
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139433/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11250701/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/bcr43
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