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Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
p27 is a key regulator of progression from G1 to S phase. Although the gene encoding p27 is rarely mutated in human cancers, p27 is functionally inactivated in a majority of human cancers through accelerated p27 proteolysis, through sequestration by cyclin D–cyclin-dependent kinase complexes and by...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314445/ https://ncbi.nlm.nih.gov/pubmed/14680481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr722 |
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