Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
p27 is a key regulator of progression from G1 to S phase. Although the gene encoding p27 is rarely mutated in human cancers, p27 is functionally inactivated in a majority of human cancers through accelerated p27 proteolysis, through sequestration by cyclin D–cyclin-dependent kinase complexes and by...
Gespeichert in:
| Veröffentlicht in: | Breast Cancer Res |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2003
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314445/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14680481/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/bcr722 |
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