The role of chromosomal instability in tumor initiation

Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per...

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Autors principals: Nowak, Martin A., Komarova, Natalia L., Sengupta, Anirvan, Jallepalli, Prasad V., Shih, Ie-Ming, Vogelstein, Bert, Lengauer, Christoph
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC138593/
https://ncbi.nlm.nih.gov/pubmed/12446840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202617399
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