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The role of chromosomal instability in tumor initiation

Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per...

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Autori principali: Nowak, Martin A., Komarova, Natalia L., Sengupta, Anirvan, Jallepalli, Prasad V., Shih, Ie-Ming, Vogelstein, Bert, Lengauer, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC138593/
https://ncbi.nlm.nih.gov/pubmed/12446840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202617399
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